C-statistics analyses to assess the involvement of EVs in the pathophysiology and severity of disease in HF-Isch, showed that activated leukocytes (CD11b+/AV+) had the best discrimination power, with an AUC of 0.848 ± 0.058 (95% CI: 0.734–0.961; p < 0.001), followed by activated neutrophils (CD29+/CD15+/AV+), with and AUC of 0.811 ± 0.065 (95% CI: 0.683–0.939; p = 0.001). Here, FUT4 is linked to hydrops fetalis.