Analysis of human blood sample sequencing datasets and mouse myocardial infarction sequencing datasets as well as cardiomyocyte hypoxia experiments indicated that FRGs ALOX5, CAMKK2, KDM6B, LAMP2, PTEN, PTGS2, and ULK1 may be potential biomarkers of AMI. Here, PTEN is linked to myocardial infarction.