Importantly, weight reduction decreases levels of CRP, IL-6, and TNF-α and lowers sICAM-1, sVCAM-1, and P-selectin .CRP and sICAM-1 as indices of inflammation and vWF and sVCAM-1 as indices of endothelial dysfunction were independently associated with increased CVD mortality, together explaining about 43%of the excess CVD risk29. The gene discussed is SELP; the disease is endothelial dysfunction.