In this study, we investigated the synergistic effects of juglone and selenium on PANC-1 and BxPC-3 pancreatic cancer cell lines by cell adhesion and invasion assays and evaluation of the mRNA and protein expressions of CDH1, ITGB3 and COL4A3 which play role in metastasis and angiogenesis processes. The gene discussed is CDH1; the disease is familial pancreatic carcinoma.