In our previous study5, for the first time we demonstrated the cytotoxic effect and also antiinvasive and antimetastatic features of the juglone in PANC-1 and BxPC-3 pancreatic cancer cells by adhesion/invasion test and evaluating MMP-2, MMP-9 and Phactr-1 gene expressions which are important markers for metastatic process. This evidence concerns the gene MMP9 and familial pancreatic carcinoma.