These SNPs in IL- 4 promoter region affect its transcription, thus producing altered IL-4 protein levels leading to either higher or lower IgE titres.16,17 So SNPs in IL-4 gene can impact the intensity of various infections16,18,19,24,47, including enteric pathogens.11,25,48 Previously complete screening of IL-4 gene was done to study polymorphisms relating to various diseases like asthma and IgE in children but no SNPs were found in exon 4 which could be relating to diseases.23,47. The gene discussed is IGHE; the disease is asthma.