In addition to these general factors, new molecular markers and genetic variations are being recognized as predictors of oral cancer prognosis.10 These include some MicroRNAs11,12, certain p53 mutations13, human papilloma viral oncogene14,15, and four new protein-signature (EGFR, HER2/neu, LAMC2 and RHOC)16 which have been associated with the risk of metastasis and poor prognosis. The gene discussed is RHOC; the disease is lip and oral cavity carcinoma.