After adjustments were made for the potential confounders, compared with the low TyG index and CRP group, participants with only an elevated TyG index or with an elevated TyG index and CRP had a 1.41-fold (HR [95%] CI: 1.41, 1.16-1.72) and 1.74-fold (HR [95%] CI: 1.74, 1.31-2.28) elevated risk of CRC. Here, CRP is linked to colorectal carcinoma.