Conversely, the increased activity of caspase-3, an early apoptotic marker, upon RSV exposure suggests that apoptotic pathways might be implicated in the antitumoral effect of RSV in longer exposure to this phytochemical, as previously described in human colorectal cancer cells (64) and human lung adenocarcinoma A549 cells (65). The gene discussed is CASP3; the disease is lung adenocarcinoma.