INS and obesity due to melanocortin 4 receptor deficiency: Nonetheless, the insulin secretion was still higher than that of the patients in the other three subgroups of obesity (median insulinAUC 14390 vs. 5797–12319 mU/I·min in the other three subgroups) and in the NW controls (median insulinAUC 6915 mU/I·min) at 12-month post-surgery (Table 2).