After bariatric surgery, both insulin resistance (median HOMA-IR decreased by 74.6% and median WBISI increased by 1.87-folds) and insulin secretion (median HOMA-beta increased by 36.1%; median IGI increased by 2.85-fold) were relieved, together with a greatly relieved DI [median DI (HOMA-beta/HOMA-IR) increased by 5.07-fold, median DI (IGI · WBISI) increased by 7.19-fold] and glycemia (median glucoseAUC decreased by 45.2%, median HbA1c decreased by 27.2%). This evidence concerns the gene INS and Insulin resistance.