For self-completeness, here is a brief summary of the four subtypes: i) metabolic healthy obesity (MHO), characterized by a relatively healthy-metabolic status with the lowest incidences of comorbidities; ii) hypermetabolic obesity-hyperuricemia (HMO-U), characterized by high uric acid but still relatively healthy glucometabolism; iii) hypermetabolic obesity-hyperinsulinemia (HMO-I), distinguished by overcompensated insulin secretion and hypoglycemia; and iv) hypometabolic obesity (LMO), characterized by decompensated insulin secretion, high glucose, and the worst glucolipid metabolism. The gene discussed is INS; the disease is hyperinsulinism.