The 2019 EULAR/ACR classification criteria for SLE include a positive ANA test followed by additive weighted criteria that are grouped into seven clinical (constitutional, hematological, musculoskeletal, mucocutaneous, serosal, renal, neuropsychiatric) and three immunological (SLE-specific antibodies, anti-phospholipid antibodies, complement proteins,) domains; weighted from 2 to 10. The gene discussed is VTN; the disease is systemic lupus erythematosus.