The BTBR mouse model of autism deals with multisystem physiological and behavioral alterations, including social behavior deficits and a reduced number of bromodeoxyuridine (BrdU)+ cells, doublecortin (DCX)+ cells, nestin+ cells, and glial fibrillary acidic protein (GFAP)+ Sox2+ cells in the hippocampus, but researchers can normalize their neurogenesis and social behavior by transplanting human amniotic epithelial cells (Zhang R. et al., 2019). The gene discussed is SOX2; the disease is autism.