In our work, transcriptomics, proteomics, and metabolomics studies were performed on human renal cancer cell (OSRC-2) samples, composed of cells transfected with the negative control virus (NC) and SLC39A1 lentivirus (ZIP), aiming to identify key alteration arising from SLC39A1 in RCC. The gene discussed is SLC39A1; the disease is renal carcinoma.