ASCL4 was considered as a sensitive monitor as well as an important contributor of ferroptosis and eliminated the inhibition of GPX4 on ferroptosis in osteosarcoma cells, and overexpression of ACSL4 in glioma significantly reduced GPX4 level and contributes to ferroptosis (Yuan et al., 2016; Cheng et al., 2020). Here, ACSL4 is linked to central nervous system cancer.