Among them, the expression levels of TCA cycle-related protein Suclg1 and lysosome-related protein Lamp2 were both significantly upregulated in the model:control group and reduced in the ZBPYR:model group, indicating that liver MAM in T2DM rat with chronic psychological stress suffers from dysfunctions of carbohydrate metabolism and lysosome-related processes. Here, SUCLG1 is linked to type 2 diabetes mellitus.