Although the expression of RASopathies-associated SHP2 variants in fruitfly induces phenotypes that are not directly translatable to NS or NSML in human patients, these studies serve not only as a prominent tool to understand basic pathogenesis principles of RASopathies-associated SHP2 variants, but also to perform drug screens and understand variant-specific phenotypes, downstream signaling differences and drug response, as demonstrated recently for the first time by Das et al. (Das et al., 2021). Here, PTPN11 is linked to RASopathy.