The overall m6A level was elevated in the cortex and the hippocampus of APP/PS1 (Alzheimer’s disease) mice compared to C57BL/6 control mice, and FTO was found to interact with APOE, which was associated with Alzheimer’s disease risk in a prospective cohort study (Keller et al., 2011; Han et al., 2020). Here, FTO is linked to early-onset autosomal dominant Alzheimer disease.