miCLIP analysis showed that METTL3 enhanced the m6A methylation of target genes such as Bcl2, Myc and Pten in the human acute myeloid leukaemia (AML) MOLM-13 cell line, which promoted the mRNA translation of these genes, thereby retaining pluripotency properties and inhibiting cell differentiation. Here, MYC is linked to acute myeloid leukemia.