PTK2 and neoplasm: Moreover, growing evidence has revealed that FAK is involved in the regulation of multiple tumorigenic processes, including growth factor signaling, cell cycle progression, cell survival, migration, metastasis, angiogenesis, and the establishment of an immunosuppressive tumor microenvironment (TME) through kinase-dependent and independent scaffolding functions in the cytosol and nucleus (Haskell et al., 2003; Kobayashi et al., 2009; Osipov et al., 2019).