High expression of the transcriptional and epigenetic regulator, Bromodomain-containing protein 4 (BRD4), during HFD consumption can be inhibited by JQ1, a chemical inhibitor of BRD4, resulting in increased PINK1-Parkin-dependent mitophagy and alleviation of the structural and functional changes associated with diabetic cardiomyopathy (51). Here, PRKN is linked to diabetic cardiomyopathy.