In fact, TAT-Beclin1 (TB1), a cell-permeable short peptide that potently induces autophagy and mitophagy by mobilizing endogenous Beclin1 from its intracellular storage site, can reactivate or enhance mitophagy under a wide variety of conditions, thereby alleviating obesity-induced cardiomyopathy (22). The gene discussed is BECN1; the disease is obesity due to melanocortin 4 receptor deficiency.