LDHA and cancer: Diverse inhibitors of LDHA, such as FX-11, AZ-33, and NHI-2 (Granchi et al., 2013; Xie et al., 2014; Augoff et al., 2015), alter cancer cell survival through ROS accumulation, and knockdown of LDHA approaches similar effects (Le et al., 2010; Sheng et al., 2012).