VEGFA and coronary artery disorder: Angiogenesis is an essential event involved in ischemic heart disease, which promotes the growth of new capillary blood vessels and restores the blood flow of ischemic tissue (Tabibiazar and Rockson, 2001), and is regulated by secreted angiogenic growth factors such as vascular endothelial growth factor-A (VEGFA) and angiopoietin-1 (Angpt1), etc. (Breier et al., 1997).