To evaluate whether elevating Hif-1α improves cardiac angiogenesis in 5/6Nx mice fed by high-choline diet, we treated them with FG-4592, a stabilizer of Hif-1α, which has been used to treat renal anemia in CKD patients (Voit and Sankaran, 2020; Hu et al., 2021). The gene discussed is HIF1A; the disease is chronic kidney disease.