TUBA1A and tubulinopathy: Whether TUBA1A tubulinopathy mutants all act through a common mechanism of haploinsufficiency was called into question in 2010, when Tian et al. (2010) investigated nine additional tubulinopathy disease-associated mutants in TUBA1A [I188L, P263T, L286F, R402C, R402H, S419L, I238V, and L397P].