IL1B and Cognitive impairment: Table 1 summarizes the key proinflammatory cytokines and neurotrophins associated with cognitive impairment in psychiatric disorders. The number of inflammatory cytokines is indeed associated with an increased risk of psychosis, most notably IL-1β, IL-6, TNF-α, CRP, and BDNF, although the current literature remains inconsistent (Kogan et al., 2020).