BDNF and Cognitive impairment: In ASD, loss-of-function mutations in JARID1C, an X-linked gene encoding H3K4 demethylase, may also be associated with cognitive impairment, as it regulates autism and cognitive dysfunction genes such as SCN2A, CACNA1H, BDNF, and SLC18A1 (Adegbola et al., 2008; Shen et al., 2014).