SCZ patients exhibited defective expression of histone H3K4-trimethylation (H3K4me3) and GABAergic promoter subsets of genes (GAD1, GAD2, NPY, and SST) in the prefrontal cortex, all of which are strongly associated with cognitive impairment (Huang et al., 2007; Gupta et al., 2010). The gene discussed is GAD1; the disease is Cognitive impairment.