Meanwhile, our behavioral data indicated that interference of the GRIP1-GluA2 interaction in D1-MSNs has a similar tendency to the results obtained when all types of neuronal targets are interfered by GRIP1-siRNA (Figures 2, 3, 6, 7), which illustrates that GRIP1 in D1-MSNs plays a leading role in cocaine addiction. This evidence concerns the gene GRIA2 and cocaine dependence.