MAPT and frontotemporal dementia: Frontotemporal dementia (FTD) is a type of dementia with neuropathological features involving chronic atrophy in the frontal and neocortex as well as the accumulation of microtubule-associated protein tau and two RNA-binding proteins, 43-kDa TAR DNA-binding protein (TDP-43) and fused in sarcoma (FUS) (Hoffman et al., 2019).