C9orf72 and amyotrophic lateral sclerosis: Several genetic variants in non-neuronal cells have been linked to the pathogenesis of ALS, including the 43-kDa TAR DNA-binding protein (TDP-43) and superoxide dismutase 1 (SOD1), and C9orf72 and the expression of these genes are linked to immunological neuroinflammation in ALS (Beers and Appel, 2019).