Wu et al. have found that LPS accelerates glycolysis through the nuclear factor-κB/snail/hexokinase3 signaling axis to promote CRC metastasis (Wu et al., 2021a), and Liu et al. have found that activation of p38 mitogen-activated protein kinase pathway by LPS aggravates postoperative intestinal obstruction in CRC patients (Liu et al., 2022). Here, SNAI1 is linked to intestinal obstruction.