The SNP rs738409 (C > G) is a missense variant of the patatin like phospholipase domain containing 3 (PNPLA3) gene which has been confirmed to be associated with the risk of NAFLD in multiple GWASs (Chambers et al., 2011; Sookoian and Pirola, 2011). Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.