The HCV also can infect the extra-hepatic tissue and can increase the incidence of several diseases, including autoimmune disorders (Yang et al., 2014), diabetes (Arase et al., 2009), nervous disorders (Mariotto et al., 2014), and chronic kidney disease (Sumida et al., 2010), indicating the systemically image system is the suitable approach to detect the distribution of NS3/4A protease activity. Here, KRAS is linked to chronic kidney disease.