For the KEGG pathway analysis of transcriptomics profile, DEGs associated with SMPS relative to the VPA group were mostly enriched in oxidative phosphorylation, retrograde endocannabinoid signaling, thermogenesis, Parkinson disease, ribosome, protein digestion and absorption, renin-angiotensin system, calcium signaling pathway, phenylalanine metabolism, glycosphingolipid biosynthesis-ganglio series, and propanoate metabolism, etc. (Figure 8B; Supplementary Table S1). This evidence concerns the gene REN and Parkinson disease.