Univariate logistic regression analysis showed that age, type 2 diabetes, old cerebral infarction, chronic obstructive pulmonary disease, cough, pulmonary rales, petechiae/ecchymosis, oral hemorrhage, hematemesis/melena, atrial fibrillation, atrial/ventricular premature beats, as well as high-level SFTSV load, PT, APTT, TT, ALT, AST, BUN, Cr, LDH, CK, α-HBDH, K, and low-level PLT and Ca during the fever stage were the risk factors of central neurological complications in SFTS patients. This evidence concerns the gene GPT and chronic obstructive pulmonary disease.