In addition, since the ablation of each part of the NLRP3 inflammasome helps prevent age-related cognitive decline caused by neuroinflammation and neurodegeneration, such as in Alzheimer's disease (16–18), we deduce that the NLRP3 inflammasome can be immensely valuable as a potential therapeutic target for PND. The gene discussed is NLRP3; the disease is early-onset autosomal dominant Alzheimer disease.