The results showed that no significant difference was found among the protein expression of ADRB2 with sex, age, tumor size, INSS stage, marrow and bone metastasis, but the results indicated that the positive expression of ADRB2 was related to Shimada classification (P = 0.0220) and N-MYC non-amplification (P = 0.0166). Here, ADRB2 is linked to neoplasm.