CAT and neurodegenerative disease: Mitochondria are considered a major intracellular ROS producer.2 Under normal physiological conditions, ROS homeostasis is maintained by several enzymes such as superoxide dismutase and catalase, but conditions such as aging, cancer, and degenerative diseases are known to be caused by mitochondrial defects and are associated with elevated ROS levels.3–52 Here, we explored if the mechanical properties of mitochondria are linked to levels of intracellular superoxide.