In the subsequent reverse validation test, targeted down-regulation of lncRNA BACE1AS expression in SH-SY5Y cells attenuated the ability of BACE1 to cleave APP and slowed the formation of senile plaques in SP AD SH-SY5Y model (Faghihi and Wahlestedt, 2009; Liu et al., 2014). Here, APP is linked to Alzheimer disease.