Of the glycosyltransferases that modify Notch EGF repeats and promote hematopoiesis, deleterious mutations compatible with life in humans have been identified in POFUT1, LFNG, and EOGT. Mutations in POFUT1 cause an autosomal dominant disease termed Dowling Degos Disease 2 (DDD2) which causes skin hyperpigmentation and follicular skin lesions (Li et al., 2013). This evidence concerns the gene POFUT1 and neoplasm.