MTOR and central nervous system cancer: Although FoxL1 overexpression is associated with gliomas (Chen et al., 2019), the FoxL group of TFs is less well studied, but a connection between FoxL1 and cell survival was established through the PI3K/Akt/mTor signaling pathway, which was impacted upon through the differential expression of ECM molecules such as Col9a1 (high in NP cells) and Col1a1 and LamC2 (both lower in NP cells) (Ryu and Lee, 2017).