Of note, a single amino acid ADPKD patient mutation L4132Δ (Afzal et al., 1999) was found to block basal and augmented AP-1 activity as well as PC1/PC2 channel activity in electrophysiological studies in CHO cells (Parnell et al., 2018). The gene discussed is PKD1; the disease is autosomal dominant polycystic kidney disease.