It was explained that circulating exosomes of patients with T2DM contained lower serpin G1 levels (also known as C1 inhibitor) compared to healthy controls (Kanwar et al., 2014) which is probably because T2DM also happens due to low levels of serpin G1 content in small EVs of obese individuals as it can inhibit several other factors (such as kallikrein and factor IIa) that create disrupted immune responses in T2DM patients (Davies et al., 2012). The gene discussed is KLK4; the disease is type 2 diabetes mellitus.