METTL3 and liver cancer: Chen et al. (2018) found interference with METTL3 reduce the expression of SOCS2 mRNA. Second, it was reported that METTL14 is downregulated in liver cancer, and thereby regulates the development of liver cancer (Bartosovic et al., 2017; Ma et al., 2017). Together these evidences suggest that m6A modification has a key role in liver-related diseases through various m6A-related proteins (Wu et al., 2019; Wu et al., 2020; Kim and Siddiqui, 2021b; Wang and Zhou, 2022). Modification of m6A methylation is involved in the pathogenesis of liver injury, organ failure, and fibrosis.