By proteomic sequencing of specimens from patients with positive and non-positive lymph node metastases, significantly increased expression of SPOP was found in patients with positive lymph node metastasis, and it can induce immune tolerance spatially and functionally through promoting PD-1 away from PD-L1 (Wu et al., 2022). This evidence concerns the gene CD274 and metastatic malignant neoplasm in the lymph nodes.