In the low-risk group, upregulation of activity was observed for most steps in the cycle, including priming and activation (step 3), transport of immune cells to the tumor (step 4) (T-cell recruiting, CD4 T-cell recruiting, CD8 T-cell recruiting, Th1 cell recruiting, DC cell recruiting, Th22 cell recruiting, macrophage recruiting, NK cell recruiting, Th17 cell recruiting, B-cell recruiting, Th2 cell recruiting, Treg cell recruiting), Infiltration of immune cells into tumors (Step 5), Recognition of cancer cells by T cells (Step 6), Killing of cancer cells (Step 7) (Figure 9F). Here, CD8A is linked to cancer.