GPT and acute kidney injury: For the first AE signature, AEs with top probabilities include some liver-related symptoms (alanine aminotransferase increased, aspartate aminotransferase increased, and blood creatinine increased), kidney-related symptoms (acute kidney injury and glomerular filtration rate decreased), and cardiovascular-related symptoms (bradycardia, cardiac arrest, and hypotension) (Supplementary Figure S1).