Tumor cell immunohistochemical PD-L1, plasma soluble PD-L1 (sPD-L1), TMB/blood TMB (bTMB), mismatch repair defect (dMMR)/microsatellite instability-high (MSI-H), and other biomarkers such as KRAS, STK11, KEAP1, and DNA damage response (DDR) gene variation are potential biomarkers (Doroshow et al., 2019). The gene discussed is KRAS; the disease is neoplasm.