Our results showed that MMP9, MMP2, PPARA, PTPRC, NOS3, TLR2, and HSP90AA1 were differentially analyzed in the sepsis survivor-control group (SS-C), sepsis non-survivor-control group (SN-C), p-value were all <0.05, there was the differential expression, indicating that key genes were related to the occurrence of sepsis. The gene discussed is HSP90AA1; the disease is Sepsis.