There are some studies have shown that activation of the PI3K/Akt pathway can promote the expression of heme oxygenase-1 (HO-1), which in turn plays an anti-apoptotic or anti-inflammatory role in the oxidative damage response and improves multiple organ dysfunction in sepsis (Kim et al., 2018; Xiao et al., 2018). This evidence concerns the gene HMOX1 and Sepsis.