It has been shown that mutations in the LHR gene lead to abnormal LHR function and failure to properly receive LH and stimulate hormonal signaling to the second messenger, resulting in impaired follicular maturation in the ovary, anovulation, delayed puberty, amenorrhea, infertility, with typical POF symptoms (Dixit et al., 2010). This evidence concerns the gene LHCGR and amenorrhea.