Our data, based on human caudate nucleus tissue samples from postmortem brains provide useful insight into novel potential tissue markers of AD, Firstly, TBXAS1 mRNA, a marker of platelet aggregation or atheroprone vasculature (Ramazi et al., 2019) is positively detected in all caudate nucleus samples of AD, while TBXAS1 mRNA is not always detectable in controls. Here, TBXAS1 is linked to Alzheimer disease.