We confirmed the previous finding that MAPT and APP mRNA are elevated in the caudate nucleus (tissue), consistent with fluid assays of AD (Musiek and Holtzman, 2012; Lafirdeen et al., 2019; McLimans et al., 2019; Barthelemy et al., 2020; Shen et al., 2020; Shen et al., 2021). This evidence concerns the gene APP and Alzheimer disease.