The goal of this study was to quantify relative mRNA levels of TRPV4, ZCCHC8, VEGF, TBXAS1, MAPT, and APP, in postmortem human caudate nucleus samples from elderly (>66 years of age) cadaveric donors previously diagnosed with NPH and AD as compared to unaffected controls. Here, ZCCHC8 is linked to Alzheimer disease.