Nevertheless, we envision that the data presented in this report on a more specific marker gene like TRPV4 and MAPT in NPH can significantly improve the prior cases reporting misdiagnosis of either AD or NPH (Joseph et al., 2006; Joseph et al., 2008; Lee et al., 2010; Shimada et al., 2011). This evidence concerns the gene MAPT and normal pressure hydrocephalus.