The analysis of the interrelation between TTC21A expression and diverse immune infiltration cell in ccRCC showed the expression of TTC21A was negatively correlated with infiltration level of B cells, NK CD56dim cells, TFH, DC, macrophages, iDC, Th2 cells and Tgd. The gene discussed is ABCA1; the disease is nonpapillary renal cell carcinoma.