Human STAT3 plays a significant role in the pathogenesis of herpesviruses and varicella-zoster virus (VZV) as shown by Sen et al. and STAT3 mutations cause autosomal dominant hyper-IgE syndrome, a rare disorder of immunity characterized by elevated IgE levels and recurrent bacterial infections in skin and lung (11–15). The gene discussed is STAT3; the disease is Autosomal dominant hyper-IgE syndrome.