In cervical cancer, high expression of PDIA3 was associated with DNA methylation and negatively correlated with B cell memory (r = −0.132, P = 0.021), T cell regulatory (r = −0.127, P = 0.026), monocytes (r = −0.204, P = 0), and macrophages M2 (r = −0.142, P = 0.013), whereas positively correlated with levels of NK cell activated (r = 0.162, P = 0.005) and mast cells activated (r = 0.119, P = 0.037). The gene discussed is PDIA3; the disease is cervical carcinoma.