During the progression of atherosclerosis, (Figure 8(b)) TGF-β (3,159 ± 106 vs 2,483 ± 68 pg/mL, respectively; P < 0.001) and IL-10 (26.78 ± 1.74 vs 19.37 ± 2.19 pg/mL, respectively; P = 0.02) were showed higher levels in the mice treated with IL-27 than in those treated with PBS, while IFN-γ (16.67 ± 0.90 vs 21.88 ± 1.36 pg/mL, respectively; P = 0.01) and IL-17 (19.98 ± 1.28 vs 31.85 ± 2.24 pg/mL, respectively; P = 0.001) were displayed lower levels. This evidence concerns the gene IL10 and atherosclerosis.