Compared to the PBS-treated mice, the mice treated with IL-27 in the early stage of atherosclerosis showed a significant 39.2% reduction in aortic plaque burden (Figure 1; 13.28 ± 0.88% vs 8.08 ± 0.87%, respectively; P = 0.002), while those treated with anti-IL-27p28-Ab showed a 32.2% increase in aortic plaque burden (Figure 1; 13.28 ± 0.88% vs 17.55 ± 1.20%, respectively; P = 0.017). This evidence concerns the gene IL27 and atherosclerosis.