Our recent studies showed that CD4+LAP+ and CD4+CD25+ Tregs are suppressed in ACS [13] and that CD4+LAP+ and CD4+CD25+Foxp3+ T cells induced by nasal-oxidized low-density lipoprotein suppress effector T cell responses and attenuate atherosclerosis in ApoE−/− mice [15]. This evidence concerns the gene APOE and atherosclerosis.