In groups modeling the progression of atherosclerosis, the proportions of LAP+ Treg (spleen: 3.3 ± 0.2% vs 1.34 ± 0.09%, respectively; P < 0.001; Figure 3) (blood: 1.34 ± 0.06% vs 0.81 ± 0.03%, respectively; P < 0.001; Figure 4), and Foxp3+ Treg (spleen: 5.7 ± 0.2% vs 4.3 ± 0.2%, respectively; P < 0.001; Figure 3) (blood: 8.6 ± 0.2% vs 6.3 ± 0.3%, respectively; P < 0.001; Figure 4) were upregulated in the mice treated with IL-27 compared with those treated with PBS. This evidence concerns the gene IL27 and atherosclerosis.