Compared with the mice treated with PBS, the mice treated with IL-27 in the early stage of atherosclerosis exhibited a 33.7% reduction in the aortic sinus atherosclerotic lesion size (mean aortic sinus plaque area 415.3 ± 40 × 103 μm2 vs 275.2 ± 40 × 103 μm2, respectively; P = 0.03; Figure 1). This evidence concerns the gene IL27 and atherosclerosis.