As shown in Figure 4A, ZIKV infection significantly upregulated genes related to lysosomal biosynthesis, including LAMP1 and CLCN7 (lysosomal transmembrane proteins); CSTB and CSTD (lysosomal hydrolases); and ATP6V1C1 and ATP6V0D1 (v-ATPase proteins). This evidence concerns the gene LAMP1 and Zika virus infectious disease.