Infection with SARS-CoV-2 induced a significant increase in IFN-γ (p <0.0001), IL-6 (p <0.0001) and IL-10 (p <0.0001) expression in the lung tissue of the Saline group and AdC68-empty group animals at dpi 3, while induction of IL-6 (Saline group: p <0.0001) and IL-10 (Saline group: p <0.0001; AdC68-empty group: p <0.001) at dpi 7 was maintained. This evidence concerns the gene IFNG and infection.